Publications - Complexity-Inspired Organic Synthesis LAB

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(Google scholar: https://scholar.google.co.kr/citations?user=3vEMzoEAAAAJ&hl=en)

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From Seoul National University, South Korea:

Adventures in Total Synthesis – The Next Chapter. (Dedicated to Professor Ian Paterson and Professor K. C. Nicolaou) SynLett. 2024, 35, 1345-1360 (Invited contribution to Synlett Account by Peter C. Vollhardt)
Stereo-controlled Synthesis of Vicinal Tertiary Carbinols: Application in the Synthesis of a Diol Substructure of Zaragozic Acid, Pactamycin and Ryanodol. Chem. Eur. J. 2023, 29, e202301938 (Dedicated to Professor Ian Paterson on the occasion of his retirement)
Contemporary Accounts in Drug Discovery and Development: Chapter 15 Accelerating Drug Discovery and Development: Translational Medicine in Combating the COVID-19 Pandemic (With X. Huang and W. H. Tang, Pages: 385-420). Ed. X. Huang, R. G. Aslanian, and W. H. Tang, John Wiley & Sons, Inc. 2022
Contemporary Accounts in Drug Discovery and Development: Chapter 14 Combination Therapy Case Studies in Anticancer and Anti-Infectious Disease Drug Discovery and Development (With X. Huang, Pages: 341-384). Ed. X. Huang, R. G. Aslanian, and W. H. Tang, John Wiley & Sons, Inc. 2022
Late-Stage and Strain-Accelerated Oxidation Enabled Synthesis of Haouamine A. Chem. Sci., 2020, 11, 8132-8137
(Author Profile) Angew. Chem. Int. Ed. 2019, 58, 13624
A Local-Desymmetrization-Based Divergent Synthesis of Quinine and Quinidine. Angew. Chem. Int. Ed. 2019, 58, 488-493 (In memory of Professor Gilbert Stork)
A Desymmetrization-Based Total Synthesis of Reserpine. Angew. Chem. Int. Ed. 2018, 57, 16152-16156 (Cover page) (Dedicated to Professor E. J. Corey on the occasion of his 90th birthday)
A Personal Perspective on Organic Synthesis: Past, Present, and Future, Special Issue: Rosarium Philosophorum – Organic Synthesis. Isr. J. Chem. 2018, 58, 85-93 (Dedicated to Professor Dieter Seebach on the occasion of his 80th birthday)
A Desymmetrization-Based Approach to Morphinans: Application in the Total Synthesis of Oxycodone. Chem. Commun., 2018, 54, 13018-13021
Total Synthesis of Strychnine. Chem. Eur. J. 2017, 23, 16189-16193 (Dedicated to Professor Robert Burns Woodward)
Asymmetric Total Syntheses of Communesin F and a Putative Member of the Communesin Family. Angew. Chem. Int. Ed. 2017, 56, 14237-14240 (In memory of Carlos F. Barbas III)
Organocatalytic and Late-Stage CH-Functionalization Enabled Asymmetric Synthesis of Communesin F and Putative Communesins (Special Issue: Synthesis of Antibiotics and Related Molecules). J. Org. Chem. 2018, 83, 6936-6957
An Asymmetric Pathway to Dendrobine by a Transition-Metal-Catalyzed Cascade Process. Angew. Chem. Int. Ed. 2017, 56, 12250-12254
Total Synthesis of Actinophyllic Acid. Angew. Chem. Int. Ed. 2017, 56, 12277-12281 (Dedicated to Professor Yoshito Kishi on the occasion of his 80th birthday)
Programmed Serial Stereochemical Relay and its Application in the Synthesis of Morphinans. Chem. Sci., 2017, 8, 7031
Synthesis of the C18-Norditerpenoid Alkaloid Neofinaconitine: A Lesson in Convergent Synthesis Planning. Angew. Chem. Int. Ed. 2014, 53, 924-926 (In memory of David Y. Gin)
(Editorial) Transition-metal and organocatalysis in natural product synthesis (with D. Ma) Beilstein J. Org. Chem. 2013, 9, 1192-1193
Modern Tools for the Synthesis of Complex Bioactive Molecules: Metathesis-based Synthesis of Complex Bioactives. Ed. J. Cossy and S. Arseniyandis, John Wiley & Sons, Inc. 2012
A Case Study of Single-Pill Combination Therapy: The Ezetimibe/Simvastatin Combination for Treatment of Hyperlipidaemia (with X. Huang) ChemMedChem. 2012, 7, 1882-1894
Recent Advances in the Total Synthesis of Cyclopropane Containing Natural Products. Chem. Soc. Rev. 2012, 41, 4631-4642
C–H Activation: A Complementary Tool in the Total Synthesis of Complex Natural Products. (with S. W. Youn) Chem. Eur. J. 2012, 18, 9452-9474 (Dedicated to Professor Gilbert Stork on the occasion of his 90th birthday)
A Mast Cell Degranulation Screening Assay for the Identification of Novel Mast Cell Activating Agents. MedChemComm. 2013, 4, 88-94 (New Talent Issue, Invited by Co-Editor-in-Chief: Gregory Verdine)
The Chemistry of the Polycyclic Polyprenylated Acylphloroglucinols (PPAPs) Angew. Chem. Int. Ed. 2012, 51, 4536-4561 (In memory of David Y. Gin)
A Chiral-Pool Based Approach to the Core Structure of (+)-Hyperforin. Eur. J. Org. Chem. 2012, 3, 484-487
Chemical Synthesis of the Englerins (Dedicated to Professor K. C. Nicolaou for his contribution in chemical education in Singapore and on the occasion of his 65th birthday) Chem. Asian J. 2012, 7, 22-35 (Invited contribution by Editor-in-Chief: Peter Gölitz)
Adventures in Total Synthesis – A Personal Account. (Dedicated to Professor K. C. Nicolaou on the occasion of his 65th birthday) Synlett. 2011, 17, 2459-2481 (Invited contribution to Synlett Account by Editor-in-Chief: Peter C. Vollhardt)
Lagunamide C, a Cytotoxic Cyclodepsipeptide from the Marine Cyanobacterium Lyngbya majuscule. Phytochemistry 2011, 18, 2369-2375
Total Synthesis of Echinopines A and B: Exploiting a Bioinspired Late-Stage Intramolecular Cyclopropanation. Org. Lett. 2011, 13, 5724–5727
A Modular Synthesis of Salvileucalin B Structural Domains. Org. Lett. 2011, 13, 4410-4413

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From Institute of Chemical and Engineering Sciences, A*STAR, Singapore:

Synthesis of ent-Nanolobatolide. Angew. Chem. Int. Ed. 2011, 50, 4165-4168
Synthesis of an Advanced Maoecrystal V Core Structure. Chem. Eur. J. 2011, 17, 5778-5781
Proteomic Signature of Fatty Acid Biosynthesis Inhibition Available for In-Vivo Mechanism-of-Action Studies. Antimicrob. Agents Chemother. 2011, 55, 2590-2596
Formal Asymmetric Synthesis of Echinopine A and B. Angew. Chem. Int. Ed. 2011, 50, 3013-3016
Chemical Synthesis and Biological Evaluation of the Englerin Analogues. 2011, 6, 420-423
A Second-Generation Formal Synthesis of (+)-Haplophytine. Eur. J. Org. Chem. 2011, 1027-1031
Formal Syntheses of (-)- and (+)-Phalarine. Angew. Chem. Int. Ed. 2011, 50, 676-679
Chemical Synthesis and Biological Evaluation of Second-Generation Palmerolide A Analogues. Eur. J. Org. Chem. 2011, 463-468
Total Synthesis and Biological Evaluation of Fab-Inhibitory Antibiotic Platencin and Analogues Thereof. Eur. J. Org. Chem. 2011, 183-196
Chemistry of the Cortistatins – A Novel Class of Anti-Angiogenic Agents. Org. Biomol. Chem. 2010, 8, 2900-2911 (Invited Perspective)
Modular Synthesis of Polyphenolic Benzopyrans, and Application in the Total Synthesis of Malibatol A and Shoreaphenol. Molecules 2010, 15, 5909-5927 (Invited contribution to special issue: Diversity Oriented Synthesis, Guest Editor: Peter Wipf)
Total Synthesis of Englerin A. J. Am. Chem. Soc. 2010, 132, 8219-8222
Total Synthesis and Biological Evaluation of the Resveratrol-Derived Polyphenol Natural Products Hopeanol and Hopeahainol A. J. Am. Chem. Soc. 2010, 132, 7540-7548
Total Synthesis of Echinopines A and B. J. Am. Chem. Soc. 2010, 132, 3815-3818
Synthesis of Functionalized Maoecrystal V Core Structures. Chem. Comm. 2010, 46, 70-72
Total Synthesis of (+)-Haplophytine. Angew. Chem. Int. Ed. 2009, 48, 7616-7620
Cortistatin A is a High-Affinity Ligand of Protein Kinases ROCK, CDK8, and CDK11. Angew. Chem. Int. Ed. 2009, 48, 8952-8957
Identification of Distinct Thiopeptide-Antibiotic Precursor Lead Compounds Using Translation Machinery Assays. Chem. Biol. 2009, 16, 1087-1096
Total Synthesis and Biological Evaluation of Cortistatin A and J and Analogues Thereof. J. Am. Chem. Soc. 2009, 131, 10587-10597
Total Synthesis of Hopeahainol A and Hopeanol. Angew. Chem. Int. Ed. 2009, 48, 3440-3443
New Synthetic Technologies for the Construction of Heterocycles and Tryptamines. J. Am. Chem. Soc. 2009, 131, 3690-3699
Total Synthesis of (+)-Cortistatin A. Angew. Chem. Int. Ed. 2008, 47, 7310-7313
An Expedient Asymmetric Synthesis of Platencin. J. Am. Chem. Soc. 2008, 130, 11292-11293
Chemical Synthesis and Biological Evaluation of Palmerolide A Analogues. J. Am. Chem. Soc. 2008, 130, 10019-10023
Total Synthesis of Amythiamicins A, B and C. Chem. Comm. 2008, 12, 2632-2634
An Expedient Strategy for the Synthesis of Tryptamines and Other Heterocycles. Angew. Chem. Int. Ed. 2008, 47, 4217-4220
Total Synthesis of the Originally Proposed and Revised Structures of Palmerolide A and Isomers Thereof. J. Am. Chem. Soc. 2008, 130, 3633-3644
Total Syntheses of Thiopeptide Antibiotics GE2270A, GE2270T, and GE2270C1. Chem. Asian J. 2008, 3, 413-429
A Chiral Pool Based Synthesis of Platensimycin. Angew. Chem. Int. Ed. 2008, 47, 944-946
Total Synthesis of the Originally Proposed and Revised Structures of Palmerolide A. Angew. Chem. Int. Ed. 2007, 46, 5896-5900
Construction of the “Left Domain” of Haplophytine. Angew. Chem. Int. Ed. 2007, 46, 4715-4718
Total synthesis of antibiotics GE2270A and GE2270T. Angew. Chem. Int. Ed. 2006, 45, 7786-7792

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From University of Cambridge (Ph.D., with Professor Ian Paterson) and The Scripps Research Institute (Postdoc, with Professor K. C. Nicolaou):

Total Synthesis and Structural Elucidation of Azaspiracid-1. Final Assignment and Total Synthesis of the Correct Structure of Azaspiracid-1. Nicolaou K. C.,* Koftis T. V., Vyskocil S., Petrovic G., Tang W., Frederick M. O., Chen D. Y.-K., Li Y., Ling T., Yamada Y. M. A. J. Am. Chem. Soc. 2006, 128, 2859-2872
Total Synthesis and Structural Elucidation of Azaspiracid-1. Synthesis-Based Analysis of Originally Proposed Structures and Indication of Their Non-Identity to the Natural Product. Nicolaou K. C.,* Chen D. Y.-K., Li Y., Uesaka N., Petrovic G., Koftis T. V., Bernal F., Frederick M. O., Govindasamy M., Ling T., Pihko P. M., Tang W., Vyskocil S. J. Am. Chem. Soc. 2006, 128, 2258-2267
Total Synthesis of Altohyrtin A/Spongistatin 1. Part 4: Fragment Couplings, Completion of the Synthesis, Analogue Generation and Biological Evaluation. Paterson I.,* Chen D. Y.-K., Coster M. J., Aceña J. L., Bach J., Wallace D. J. Org. Biomol. Chem. 2005, 3, 2431-2440
Total Synthesis of Altohyrtin A/Spongistatin 1. Part 3: The Southern Hemisphere EF Segment. Paterson I.,* Coster M. J., Chen D. Y.-K., Aceña J. L., Bach J., Keown L. E., Trieselmann T. Org. Biomol. Chem. 2005, 3, 2420-2430
The Stereocontrolled Total Synthesis of Altohyrtin A/Spongistatin 1. Part 2: The CD-Spiroacetal Segment. Paterson I.,* Coster M. J., Chen D. Y.-K., Gibson K. R., Wallace D. J. Org. Biomol. Chem. 2005, 3, 2410-2419
The Stereocontrolled Total Synthesis of Altohyrtin A/Spongistatin 1. Part 1: The AB-Spiroacetal Segment. Paterson I.,* Coster M. J., Chen D. Y.-K., Oballa R. M., Wallace D. J., Norcross R. D. Org. Biomol. Chem. 2005, 3, 2399-2409
Chemistry and Biology of Diazonamide A: Second Total Synthesis and Biological Investigations. Nicolaou K. C.,* Hao J., Reddy M. V., Rao P. B., Rassias G., Snyder S. A., Huang X., Chen D. Y.-K., Brenzovich W. E., Giuseppone N., Giannakakou P., O’Brate A. J. Am. Chem. Soc. 2004, 126, 12897-12906
Chemistry and Biology of Diazonamide A: First Total Synthesis and Confirmation of the True Structure. Nicolaou K. C.,* Chen D. Y.-K., Huang X., Ling T., Bella M., Snyder S. A. J. Am. Chem. Soc. 2004, 126, 12888-12896
Structural Revision and Total Synthesis of Azaspiracid-1, Part 1: Intelligence Gathering and Tentative Proposal. Nicolaou K. C.,* Vyskocil S., Koftis T. V., Yamada Y. M. A., Ling T., Chen D. Y.-K., Tang W., Petrovic G., Frederick M. O., Li Y., Satake M. Angew. Chem. Int. Ed. 2004, 43, 4312-4318
Total Synthesis of the Proposed Azaspiracid-1 Structure, Part 2: Coupling of the C1-C20, C21-C27, and C28-C40 Fragments and Completion of the Synthesis. Nicolaou K. C.,* Chen D. Y.-K., Li Y., Qian W., Ling T., Vyskocil S., Koftis T. V., Govindasamy M., Uesaka N. Angew. Chem. Int. Ed. 2003, 42, 3649-3653
Total Synthesis of the Proposed Azaspiracid-1 Structure, Part 1: Construction of the Enantiomerically Pure C1-C20, C21-C27, and C28-C40 Fragments. Nicolaou K. C.,* Li Y., Uesaka N., Koftis T. V., Vyskocil S., Ling T., Govindasamy M., Qian W., Bernal F., Chen D. Y.-K. Angew. Chem. Int. Ed. 2003, 42, 3643-3648
The Second Total Synthesis of Diazonamide A. Nicolaou K.C.,* Rao P. B., Hao J., Reddy M. V., Rassias G., Huang X., Chen D. Y.-K., Snyder S. A. Angew. Chem. Int. Ed. 2003, 42, 1753-1758
Synthesis and Biological Evaluation of Spongistatin/Altohyrtin analogues: E-ring Dehydration and C46 Side-chain Truncation. Paterson I.,* Aceña J. L., Bach J., Chen D. Y.-K., Coster M. J. Chem. Comm. 2003, 4, 462-463
Total Synthesis of Diazonamide A. Nicolaou K.C.,* Bella M., Chen D. Y.-K., Huang X., Ling T., Snyder S.A. Angew. Chem. Int. Ed. 2002, 41, 3495-3499
Total Synthesis of Siphonarin B and Dihydrosiphonarin B. Paterson I.,* Chen D. Y.-K., Franklin A. S. Org. Lett. 2002, 4, 391-394
Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1. Paterson I.,* Chen D. Y.-K., Coster M. J., Aceña J. L., Bach J., Gibson K. R., Keown L. E., Oballa R. M., Trieselmann T., Wallace D. J., Hodgson A., Norcross R. D. Angew. Chem. Int. Ed. 2001, 40, 4055-4060
Studies in Marine Polypropionate Synthesis: Total Synthesis of (-)-Baconipyrone C. Paterson I.,* Chen D. Y.-K., Aceña J. L., Franklin A. S. Org. Lett. 2000, 2, 1513-1516